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Endocrine Abstracts

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ea0047oc6 | Spotlight on Neuroendocrine tumours | Theranostics2016

DNA damage assay in blood lymphocytes in peptide receptor radionuclide therapy patients with personalised high activities

Eberlein Uta , Scherthan Harry , Werner Rudolph A , Lapa Constantin , Bluemel Christina , Peper Michel , Buck Andreas K , Port Matthias , Lassmann Michael

Objectives: Radiation induces DNA double strand breaks (DSBs) that can be visualized and enumerated as microscopic γ-H2AX and 53BP1 foci. This study analysed the dose- and time-dependency of the DNA damage in blood lymphocytes in patients after a personalised high-activity 177Lu-DOTATATE treatment.Methods: We investigated multiple blood samples of three patients up to 96 h after personalised high-activity peptide receptor radionuclid...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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